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Objectiu de la convocatòria
Target ALS funds research aimed at understanding the fundamental biology of genetic and sporadic forms of ALS to uncover the next generation of therapeutic targets. The call invites collaborative, multidisciplinary groups with novel and innovative methods in convergent and complimentary multi-omic approaches, and applications of artificial intelligence and machine learning.
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Característiques principals
Although all groups studying disease mechanisms and novel targets for ALS are eligible to apply, priority will be given to projects that propose the study of:
Selective resilience and vulnerability
Role of central and peripheral inflammation
Altered neuronal trafficking
Lipid dysregulation
Role of RNA dysregulation in neurodegeneration
Genetic risk factors
Upstream pathways leading to TDP-43 mislocalization/aggregation
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Convocatòria (URL)
https://www.targetals.org/basic-biology-consortia/#
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Requisits
Only collaborative projects involving 3–5 laboratories working around a common theme or target will be considered.
Projects are encouraged to include investigators who are new to ALS research and bring novel technologies or core expertise from other scientific disciplines.
All collaborators must provide a signed data/IP sharing agreement between their institutions or documentation confirming that each institution’s Technology Transfer Office is aware of the collaboration and the need for such an agreement. A fully executed data/IP sharing agreement must be shared within 60 days of award notification to maintain funding eligibility.
A Principal Investigator can only participate in one LOI submission.
Principal Investigators who have two or more active competitive grants from Target ALS at the time of the LOI due date are not eligible to apply.
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Dotació
$130,000 per lab, per year maximum. The total budget for a collaborative project cannot exceed a maximum of $500,000 per year.
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Durada
2 Years
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AVÍS IMPORTANT
LOI due December 17, 2025 at 11:59 pm Pacific Time
Proposals due February 25, 2026
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